ACP-105

ACP-105 Research Standard

ACP-105 is a non-steroidal Selective Androgen Receptor Modulator (SARM) recognized for its potent, partial agonist activity at the androgen receptor (AR). Unlike traditional steroidal androgens, ACP-105 is investigated for its ability to selectively activate AR-mediated transcription in target tissues like skeletal muscle and bone, while demonstrating reduced or minimal activation in secondary sexual tissues such as the prostate. It serves as a valuable pharmacological probe for studying tissue-specific androgenic signaling, potential neuroprotective effects, and metabolic responses in muscle and bone tissue.

Technical Specifications

Mechanism of Action & Research Context

ACP-105 acts as a high-affinity partial agonist, allowing researchers to explore androgenic signaling without the broad-spectrum effects of traditional testosterone or DHT.

• Androgen Receptor Modulation: ACP-105 binds to the AR with high affinity (pEC50 ~9.0 for wild-type AR; ~9.3 for the T877A mutant). It stabilizes the receptor in a conformation that promotes the recruitment of coactivators in bone and muscle tissue, driving selective gene expression programs.

• Tissue Selectivity: A key focus of research is its favorable anabolic-to-androgenic ratio. Studies investigate its capacity to enhance muscle mass and bone density while minimizing the stimulation of androgen-sensitive prostate tissue.

• Neuroprotective Potential: Preclinical studies have utilized ACP-105 to investigate cognitive preservation, including its potential to mitigate radiation-induced memory deficits and support hippocampal function.

Research Applications

ACP-105 is a specialized reagent essential for modern endocrinology and pharmacology research.

Primary fields of laboratory investigation include:

• Muscle & Bone Homeostasis: Evaluating its influence on anabolic pathways in myogenic and osteogenic models to assess its efficacy in preventing muscle wasting or bone density loss.

• Androgen Signaling Pathways: Benchmarking the compound’s binding affinity and transactivation potential against other SARM scaffolds in comparative pharmacological studies.

• Neuro-Cognitive Research: Using animal models to map its effects on cognitive function, hippocampal AR expression, and the degradation of amyloid-beta species in neurodegenerative research contexts.

• Comparative SAR Studies: Employing the compound as a reference structure in Structure-Activity Relationship (SAR) studies to refine the design of tissue-selective androgen ligands.

Storage & Handling Guidelines

To maintain the chemical stability and experimental reliability of the compound:

• Storage Environment: Maintain at -20°C for long-term stability.

• Environmental Control: Protect strictly from light, moisture, and high temperatures.

• Handling: Allow the container to equilibrate to room temperature before opening to minimize condensation. Utilize standard laboratory safety practices and appropriate PPE, as this compound is a biologically active SARM.

• Aseptic Technique: Maintain a sterile work environment to ensure the integrity of the compound for cell culture and other sensitive laboratory applications.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.