MK-2866

MK-2866 (Ostarine / Enobosarm) Research Standard

MK-2866 (also known as Enobosarm, GTx-024, or S-22) is a high-affinity, nonsteroidal Selective Androgen Receptor Modulator (SARM) belonging to the arylpropionamide chemical class. As one of the most thoroughly documented compounds in the Selective Modulator category—with an active Phase III clinical development history—MK-2866 serves as a definitive reference standard for androgen receptor (AR) pharmacology. It is extensively utilized in in vitro assays to investigate tissue-differential AR signaling, structural activity relationships (SAR), and forensic analytical method development.

Technical Specifications

Mechanism of Action & Research Context

MK-2866 acts as a tissue-differential AR ligand, binding the androgen receptor ligand-binding domain with high affinity.

• Tissue Selectivity: Demonstrates full agonist transcriptional activity in muscle- and bone-derived cell models, while exhibiting reduced (partial agonist) activity in prostate-derived reporter models.

• Structural Profile: Its arylpropionamide scaffold, characterized by two nitrile (cyano) functionalities and a trifluoromethyl group, provides high metabolic stability and a distinct mass spectrometric fingerprint, making it a primary analyte in forensic and anti-doping research.

Research Applications

MK-2866 is utilized as a benchmark reference compound in controlled laboratory environments.

Primary fields of in vitro laboratory investigation include:

• Androgen Receptor Profiling: Conducting AR binding, competition, and transactivation assays to characterize ligand-binding domain conformation and coregulator recruitment.

• SAR Analysis: Investigating structure-activity relationships across the nonsteroidal arylpropionamide class.

• Analytical Chemistry: Developing and validating LC-MS/MS methods for the separation and detection of Selective Modulator panels.

• Forensic & ADME Research: Utilizing the well-characterized metabolite profile of MK-2866 for in vitro metabolism and forensic toxicology studies.

Storage & Handling Guidelines

To maintain the chemical stability and experimental consistency of the compound:

• Long-Term Storage: Store at -20 °C for optimal long-term stability.

• Environmental Control: Maintain in a dry, cool environment protected from light.

• Seal Integrity: Keep the vial tightly sealed after each use to prevent atmospheric degradation.

• Aseptic Technique: Use sterile laboratory tools and equipment to prevent contamination when extracting samples for experimental protocols.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or cosmetic, and is strictly prohibited for human or animal consumption. MK-2866 is included on the WADA Prohibited List under anabolic agents; researchers must ensure compliance with all applicable local, federal, and institutional regulations regarding the purchase and use of this reference material.