RAD-150 (TLB-150)

RAD-150 (TLB-150 Benzoate) Research Standard

RAD-150 (TLB-150 Benzoate) is a synthetic benzoate ester derivative of the nonsteroidal selective androgen receptor modulator (SARM) RAD-140 (vosilasarm / Testolone). By modifying the 2-hydroxy position of the parent scaffold with a benzoate group, this compound exhibits significantly altered lipophilicity and pharmacokinetic properties. In laboratory research, RAD-150 functions as a prodrug-like analog utilized to investigate ester hydrolysis kinetics, comparative metabolic profiling, and the structural influence of esterification on the benzonitrile-oxadiazole SARM class.

Technical Specifications

Mechanism of Action (Research Context)

RAD-150 is studied primarily as a prodrug analog of RAD-140. Its utility in research is defined by its pharmacokinetic evolution rather than a distinct receptor-binding mechanism independent of the parent compound.

• Ester Hydrolysis: The compound is subject to enzymatic hydrolysis via systemic esterases (found in plasma, hepatic, and intestinal tissues) to yield the parent molecule, RAD-140. Researchers use this conversion rate to model the hydrolytic stability of ester-modified SARM compounds.

• Pharmacokinetic Profiling: The benzoate modification increases the molecule’s lipophilicity compared to the parent RAD-140. This alters the partition coefficient and membrane permeability, providing researchers with a tool to compare tissue distribution and cellular uptake dynamics.

• Receptor Pharmacology: Following hydrolysis to RAD-140, the molecule acts as a high-affinity ligand for the androgen receptor (AR). RAD-150 serves as a critical benchmark for studying how the esterification process influences the temporal delivery and metabolic activation of AR-signaling pathways in in vitro models.

Research Applications

RAD-150 is a specialized reagent essential for analytical benchmarking and structure-activity relationship (SAR) investigations within the SARM class.

Primary fields of in vitro laboratory investigation include:

• Ester Hydrolysis Kinetics: Mapping the rate and pathway of conversion from RAD-150 to RAD-140 across diverse esterase-containing biological systems.

• Analytical Method Development: Establishing definitive MS/MS fragmentation patterns—specifically monitoring the characteristic loss of the benzoyl group (e.g., m/z 497.1 -> m/z 393.8)—to confirm identity in complex matrices.

• Forensic and Toxicological Research: Providing a certified reference standard for the identification of ester-modified Selective Modulators in chemical, pharmaceutical, and anti-doping forensic matrices.

• Comparative SAR Analysis: Evaluating how the addition of the bulky benzoate moiety influences the steric and electronic fit of the benzonitrile-oxadiazole scaffold within the AR ligand-binding domain.

Storage & Handling Guidelines

To maintain the chemical stability and experimental integrity of the ester:

• Long-Term Storage: Store in a dry, cool environment. For maximum stability, maintain at -20 °C.

• Environmental Control: The ester bond is susceptible to cleavage; protect strictly from moisture and basic conditions. Keep the container tightly sealed to prevent atmospheric hydrolysis.

• Light Sensitivity: Store in a dark, light-protected area to prevent photo-degradation of the aromatic scaffold.

• Aseptic Technique: Utilize clean, non-reactive laboratory tools when weighing the material to prevent contamination of the reference standard.

Regulatory & Research Note

As a benzoate ester precursor to RAD-140 (a substance listed on the WADA Prohibited List), RAD-150 is treated as a chemically equivalent precursor in regulated research environments. Analytical investigators should maintain rigorous records, as ester-modified precursors are often investigated in forensic toxicology and anti-doping method validation.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.