SLU-PP-332

SLU-PP-332 (ERR Pan-Agonist) Research Standard

SLU-PP-332 is a potent, synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRs), specifically targeting ERR-alpha, ERR-beta, and ERR-gamma. Built on a hydrazone scaffold that links a 4-hydroxybenzohydrazide core to a naphthalene ring system, this compound is a vital tool for studying mitochondrial metabolism and the transcriptional programs associated with oxidative energy expenditure. Often cited in literature as an “exercise mimetic,” SLU-PP-332 is employed to isolate and investigate the PGC-1-alpha-linked gene programs that drive mitochondrial biogenesis and fatty-acid oxidation at the nuclear-receptor level.

Technical Specifications

Mechanism of Action & Research Context

SLU-PP-332 provides a direct mechanism to modulate the ERR-driven transcriptional machinery, distinguishing its mode of action from upstream energy sensors.

• ERR Isoform Agonism: The compound stabilizes the active conformation of all three ERR isoforms, with the highest relative potency at ERR-alpha (EC50 ≈ 98 nM).
• Transcriptional Regulation: By promoting the recruitment of coactivators to the ERR binding sites, SLU-PP-332 triggers the upregulation of genes involved in mitochondrial biogenesis and fatty-acid oxidation.
• Direct Nuclear Receptor Modulation: Unlike adrenergic agonists or AMPK activators, which modulate mitochondrial activity through indirect signaling cascades, SLU-PP-332 acts directly at the nuclear receptor level to program the metabolic phenotype.
• Selectivity: The compound demonstrates high selectivity for ERRs over classical Estrogen Receptors (ER-alpha/ER-beta) and other related nuclear receptors, making it a reliable tool for isolating ERR-specific biological effects.

Research Applications

SLU-PP-332 is a specialized reagent essential for modern metabolic and biochemical research.

Primary fields of in vitro laboratory investigation include:

• Mitochondrial Biogenesis Research: Studying the molecular pathways that increase mitochondrial density and oxidative capacity.
• Metabolic Signaling: Modeling the transcriptional adaptations of endurance exercise by upregulating PGC-1-alpha-linked gene programs.
• Fatty-Acid Oxidation Studies: Investigating the enzymatic and transcriptional shifts in lipid metabolism within isolated cell lines.
• Nuclear Receptor Profiling: Utilizing the compound to map the interactome of ERR isoforms and their downstream targets in oxidative tissue.

Storage & Handling Guidelines

To maintain the chemical stability and experimental reliability of the compound:

• Storage Environment: Store in a cool, dry place. Ensure the container is securely closed to prevent degradation.
• Environmental Control: Protect from direct light and humidity.
• Handling: Utilize standard laboratory practices for handling potent research chemicals. Maintain a clean, dedicated workspace to prevent cross-contamination.
• Integrity: Always verify lot-specific analytical documentation before initiating experimental protocols.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.