Y134

Y134 Research Standard

Y134 is a synthetic small-molecule selective estrogen receptor modulator (SERM) structurally related to the benzothiophene derivative Raloxifene. Engineered for high selectivity for the estrogen receptor α (ERα) over estrogen receptor β (ERβ), Y134 serves as a precise tool for investigating estrogen signaling, receptor pharmacology, and hormone-dependent cellular pathways. By optimizing the scaffold shared with Raloxifene analogs, Y134 provides enhanced ERα selectivity, allowing researchers to study tissue-specific modulation—acting as an agonist in bone tissue and an antagonist in reproductive tissues—without the broad cross-reactivity often associated with earlier generation SERMs.

Technical Specifications

Mechanism of Action & Research Context

Y134 is utilized in experimental settings to differentiate between ERα and ERβ signaling pathways, building upon the structural framework of established benzothiophene-class SERMs like Raloxifene.

• ERα Selectivity: While structurally related to Raloxifene, Y134 is optimized to demonstrate marked affinity for ERα relative to ERβ. This selectivity allows investigators to isolate ERα-dependent gene transcription and cellular responses in a controlled laboratory environment.

• Tissue-Specific Modulation: Y134 exhibits dual-action pharmacology; it promotes estrogen-like signaling in bone tissue models while inhibiting estrogen-stimulated cellular proliferation in reproductive tissue models.

• Transcriptional Regulation: The compound modulates estrogen-dependent gene expression, acting as a critical probe for studying hormone-dependent pathway activation and receptor-ligand interactions.

Research Applications

Y134 is a specialized reagent essential for modern endocrinology and oncology research.

Primary fields of in vitro laboratory investigation include:

• Estrogen Receptor Pharmacology: Analyzing the binding affinity and functional modulation of ERα in isolated signaling systems.

• Breast Cancer Proliferation Models: Evaluating the inhibitory effects of Y134 on estrogen-stimulated cellular growth in ER-positive cancer cell lines.

• Bone Density Research: Investigating agonist-like activity in bone tissue and its potential effects on pathways governing bone homeostasis.

• Structure-Activity Relationship (SAR) Studies: Utilizing Y134 as a structural reference to evaluate the efficacy and binding potential of novel SERMs derived from the benzothiophene scaffold.

• Hormone-Dependent Gene Expression: Mapping downstream gene regulatory changes following specific ERα modulation.

Storage & Handling Guidelines

To maintain the chemical stability and experimental reliability of the compound:

• Storage Environment: Store in a cool, dry place. Maintain the container at -20°C for long-term stability.

• Environmental Control: Protect strictly from light and moisture to prevent chemical degradation.

• Handling: Utilize standard laboratory safety practices for synthetic small molecules. Allow the container to equilibrate to room temperature before opening to minimize condensation.

• Aseptic Technique: Ensure the use of sterile laboratory tools and maintain an organized, clean workspace to prevent contamination.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.