Lemairamin

Lemairamin (WGX-50 / α7nAChR Agonist)

Lemairamin, also identified in research literature as WGX-50, is a synthetic amide derivative characterized by a dimethoxyphenyl group linked to a phenylpropenamide structure. It is extensively utilized in laboratory research as a selective agonist of the α7 nicotinic acetylcholine receptor (α7nAChR). By acting on this specific receptor, Lemairamin serves as a critical probe for investigating pathways related to neuroinflammation, pain hypersensitivity, and neuroprotective signaling mechanisms in cellular models.

Technical Specifications

Research Applications

Lemairamin is a primary tool for probing the functional role of the α7 nicotinic acetylcholine receptor in various experimental biological contexts.

Primary fields of in vitro laboratory investigation include:

• α7nAChR Signaling: Utilizing the compound to trigger and study receptor activation pathways in neuronal and inflammatory cell lines.

• Neuroinflammation Research: Analyzing the role of α7nAChR modulation in attenuating inflammatory responses in microglial and astrocytic models.

• Pain Hypersensitivity Studies: Probing receptor-mediated pathways involved in the modulation of pain signaling.

• Neuroprotective Research: Investigating the compound’s effect on cellular survival pathways under conditions of stress relevant to neurodegenerative research.

• Competitive Binding Studies: Evaluating interaction profiles and receptor occupancy in the presence of other nicotinic ligands.

Storage & Handling Guidelines

To maintain the structural integrity and stability of the research material:

• Storage Environment: Store powder in a cool, dry environment at room temperature.

• Environmental Control: Keep containers tightly sealed to prevent atmospheric exposure or moisture contamination.

• Light Protection: Protect the material from direct light during storage.

• General Handling: Operate within a clean, dry laboratory environment to prevent cross-contamination.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medication, or dietary supplement, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these high-purity chemical batches solely to qualified institutions and professional investigators for authorized research purposes.