UNII-6Y24O4F92S

UNII-6Y24O4F92S (PT-141 / Bremelanotide) Research Standard

UNII-6Y24O4F92S is a synthetic cyclic peptide, widely recognized in literature as PT-141 (Bremelanotide). It is a melanocortin-derived research compound utilized as a critical pharmacological tool to investigate the activation and signaling dynamics of the melanocortin receptor (MCR) family. The peptide’s engineered cyclic structure provides the conformational rigidity required for high-affinity receptor docking, making it a specialized reference material for mapping ligand-receptor interactions, assessing Gs-protein/adenylyl cyclase/cAMP signaling pathways, and conducting structure-activity relationship (SAR) studies in controlled in vitro environments.

Technical Specifications

Mechanism of Action & Research Context

Research involving UNII-6Y24O4F92S focuses on its role as a potent agonist interacting with the melanocortin receptor (MCR) family, which includes five subtypes (MC1R to MC5R).

• High-Affinity Receptor Binding: The cyclic conformation is engineered to maximize binding affinity to specific MCR subtypes. This rigidity is essential for maintaining the bioactive structural orientation required for effective receptor activation.

• Signaling Pathway Mapping: Researchers utilize this peptide to evaluate the activation of downstream signaling cascades—particularly the Gs protein/adenylyl cyclase/cAMP pathway—allowing for the quantification of receptor-mediated responses.

• Structural Biology Applications: The compound is frequently used in binding site mapping experiments to identify critical residues within the receptor that facilitate ligand interaction and specificity.

Research Applications

UNII-6Y24O4F92S is a specialized reagent essential for modern neuro-endocrine and pharmacological research.

Primary fields of in vitro laboratory investigation include:

• Receptor Binding Assays: Determining the affinity (Ki) and potency (EC50 or IC50) of the peptide across various melanocortin receptor subtypes.

• Structure-Activity Relationship (SAR) Studies: Investigating how modifications to the cyclic peptide scaffold influence binding efficacy and receptor specificity.

• Molecular Docking Simulations: Providing experimental data to validate and refine computational models of peptide-receptor binding interfaces.

• Comparative Pharmacology: Benchmarking the binding profile of UNII-6Y24O4F92S against endogenous ligands (such as alpha-MSH or ACTH) and other synthetic MCR-targeting agents.

Storage & Handling Guidelines

To maintain the integrity and stability of the peptide, please adhere to the following protocols:

• Short-term Storage (Lyophilized): Store at room temperature for short durations, protected strictly from direct light and moisture.

• Long-term Storage (Lyophilized): For extended stability, store at -20°C or below.

• Storage (Reconstituted): If reconstituted in a buffer, store the resulting solution refrigerated at 2°C – 8°C. Minimize repeated freeze-thaw cycles to prevent structural degradation.

• General Handling: Keep the container tightly sealed. Always use sterile, dry instruments when handling the compound to prevent cross-contamination.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.