Melanotan I

Melanotan I (Afamelanotide)

Melanotan I (Afamelanotide) is a synthetic, linear peptide analog of the naturally occurring alpha-melanocyte-stimulating hormone (α-MSH). In laboratory research, it serves as a non-selective agonist of the melanocortin receptors, providing a controlled model for studying the structural determinants of melanocortin receptor (MCR) binding. It is primarily utilized in in vitro environments to map molecular binding patterns, analyze receptor affinity profiles (particularly regarding the MC1R receptor site), and investigate the structural stability of peptide chains within the melanocortin signaling system.

Technical Specifications

Research Applications

Melanotan I is a specialized research tool used to investigate the functional dynamics of the melanocortin system in laboratory-based models.

Primary fields of in vitro laboratory investigation include:

• Receptor Affinity Mapping: Quantifying the binding strength and kinetics between the peptide and specific melanocortin receptor subtypes, such as MC1R.

• Structural Comparative Analysis: Identifying conformational differences in molecular folding between the synthetic analog and endogenous peptides.

• Signaling Pathway Research: Mapping the chemical interactions and cascades initiated within controlled intracellular signaling channels.

• Ligand Docking Simulations: Validating three-dimensional computer models of molecular docking and receptor interaction.

• Photochemical Stability Studies: Analyzing the chemical behavior and structural integrity of the peptide when exposed to specific light frequencies.

Storage & Handling Guidelines

To maintain the integrity and stability of the lyophilized peptide, the following laboratory protocols are required:

• Lyophilized Material: Store at room temperature, ensuring the material is kept away from direct light.

• Reconstituted Material: Samples should be kept in a refrigerator.

• Long-Term Storage: The material must be stored in a freezer.

• Environmental Control: Make sure the container remains tightly sealed to prevent atmospheric moisture and air entry.

• Aseptic Technique: Utilize sterile tools and clean laboratory spaces during reconstitution to prevent microbial or chemical contamination.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or cosmetic product, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these high-purity research materials solely to qualified institutions and professional investigators for authorized laboratory experimentation.