Melanotan II

Melanotan II (Cyclic Heptapeptide Agonist)

Melanotan II is a synthetic, cyclic heptapeptide analog derived from the alpha-melanocyte-stimulating hormone (α-MSH). Classified as a non-selective melanocortin receptor (MCR) agonist, its unique cyclic structure provides enhanced conformational stability compared to linear analogs, making it a critical tool for investigating peptide-receptor interactions. In laboratory settings, Melanotan II is widely utilized in structural studies, molecular docking simulations, and competitive binding assays to map the binding affinity and conformational dynamics of the melanocortin receptor system in controlled in vitro environments.

Technical Specifications

Research Applications

Melanotan II is utilized as a specialized structural probe for examining peptide-receptor binding kinetics and conformational stability.

Primary fields of in vitro laboratory investigation include:

• Receptor Affinity Mapping: Quantifying the binding strength and affinity between the peptide and specific melanocortin receptor subtypes.

• Cyclic Structure Analysis: Studying how the cyclization of the peptide chain influences its conformational rigidity and resistance to degradation.

• Binding Assay Competition: Observing the displacement kinetics of the peptide in competitive binding tests against other melanocortin ligands.

• In Vitro Docking: Evaluating the three-dimensional fit and orientation of the cyclic structure within specific receptor binding pockets.

Storage & Handling Guidelines

To maintain the chemical stability and experimental validity of the lyophilized peptide:

• Lyophilized Material: Store at room temperature, ensuring the material is kept away from direct light.

• Reconstituted Material: Samples should be kept in a refrigerator.

• Long-Term Storage: The material must be stored in a freezer.

• Environmental Control: Keep the vial tightly sealed in a dry environment to prevent moisture uptake.

• Aseptic Technique: Use sterile tools to prevent cross-contamination during laboratory preparation.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or cosmetic product, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these high-purity research materials solely to qualified institutions and professional investigators for authorized laboratory research.