ALT-711 (Alagebrium Chloride)

Identity ALT-711 (alagebrium chloride) is a synthetic thiazolium compound and a member of the Advanced Glycation End-product (AGE) breaker class. It is studied for its ability to cleave AGE crosslinks in modified proteins.

Mechanism ALT-711 contains a thiazolium ring that cleaves the α-dicarbonyl crosslinks characteristic of advanced glycation end-products. The electrophilic thiazolium center reacts with the carbon–carbon bonds of these crosslinks, breaking them and releasing the previously crosslinked protein structures. This reactivity is the basis of its use as a research tool for studying AGE-crosslinked proteins in cell-free systems. Research applications

• AGE crosslink cleavage in cell-free protein systems
• Reaction-kinetics studies (spectroscopic monitoring)
• Product analysis and protein-fragment identification
• Compound stability and degradation studies

Handling and storage −20 °C for long-term storage. Amber vial, tightly sealed, protected from light. See lot COA. Analytical Identity and purity established by HPLC-UV with MS confirmation against a CAS 341028-37-3 reference standard. Lot-specific certificate of analysis supplied with every unit. Research use only. Supplied as a research reference material for in-vitro and analytical laboratory use. Not a drug, food, cosmetic, or dietary supplement. Not for use in humans or animals. No dosing information is provided or implied.