NAC (IMMUN)

This product is discontinued

NAC (IMMUN) (Immune & Redox Research Formulation)

NAC (IMMUN) is a compounded multi-component research solution designed for the investigation of synergistic biochemical pathways involving redox regulation and immune cell metabolism. By integrating N-acetyl-L-cysteine (NAC)—a potent glutathione precursor—with a balanced amino acid profile, this formulation provides a platform for studying the interplay between antioxidant defense mechanisms, nitrogen transport, and metabolic recovery in controlled in vitro environments. This solution is intended strictly for professional laboratory environments investigating oxidative stress modulation and immune-metabolic resilience.

Formulation Specifications

Each milliliter of NAC (IMMUN) is formulated with the following research-grade concentrations:

Primary Chemical Identifier (NAC):

• CAS Number: 616-91-1

• Molecular Formula: C5H9NO3S

• Molecular Weight: 163.19 g/mol

• Solvent System: Sterile water with 1% benzyl alcohol (preservative)

Mechanism of Action & Research Context

The formulation acts as a multifaceted tool to modulate cellular redox states and provide metabolic precursors necessary for immune signaling.

• Redox Regulation: N-Acetyl-L-Cysteine acts as a direct precursor to glutathione, the primary intracellular antioxidant, assisting researchers in studying the modulation of cellular redox balance and the mitigation of oxidative stress.

• Immune Metabolism: The inclusion of Glutamine and BCAAs (Valine, Isoleucine) targets immune cell energy utilization pathways, allowing for the study of fuel source availability under stress-induced metabolic conditions.

• Nitric Oxide (NO) and Signaling: The presence of Arginine facilitates the investigation of NO-related immune and vascular signaling, while the broad amino acid profile (Alanine, Glycine, Serine) supports the study of protein synthesis and repair mechanisms during immune cell activation.

Research Applications

NAC (IMMUN) serves as a standardized reference reagent for exploring the synergy between cysteine-derived antioxidants and broad amino acid metabolism.

Primary fields of in vitro laboratory investigation include:

• Antioxidant/Glutathione Pathways: Mapping the efficacy of NAC in maintaining redox homeostasis and neutralizing reactive oxygen species (ROS).

• Immune Signaling Models: Researching the metabolic requirements of activated immune cells and the role of amino acid synergy in support pathways.

• Oxidative Stress Modeling: Investigating the impact of inflammatory response models on cellular recovery and protein synthesis.

• Amino Acid Interplay: Analyzing how co-administration of precursors (e.g., Glutamine, Taurine) influences signaling output compared to individual amino acid administration.

Storage & Handling Guidelines

To maintain the chemical stability and experimental reliability of the formulation:

• Storage Environment: Store in a cool, dry environment, protected from light to prevent oxidation of the thiol (-SH) group in NAC.

• Preservative Management: The solution contains 1% benzyl alcohol; ensure containers are kept tightly sealed to prevent evaporation or microbial ingress.

• Aseptic Technique: Utilize sterile equipment when sampling. Do not introduce foreign material into the stock solution to avoid contamination.

• Temperature Control: Maintain storage at recommended temperatures (typically refrigerated for long-term stability) to ensure integrity.

References

• Zafarullah M, et al. (2003) Molecular mechanisms of N-acetylcysteine actions. Cellular and Molecular Life Sciences. 60(1):6–20.

• Newsholme P, et al. (2003) Glutamine and glutamate as vital metabolites. The Journal of Nutrition. 133(11):3684S–3687S.

• Wu G, et al. (2004) Arginine metabolism and its implications in immune function. Journal of Nutrition. 134(10):2881S–2887S.

• Calder PC. (2006) Branched-chain amino acids and immunity. The Journal of Nutrition. 136(1):288S–293S.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this compounded research formulation solely to qualified institutions and professional investigators for authorized laboratory research.

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