LL-37

LL-37 (Host Defense Peptide Research Standard)

LL-37 is a synthetic, 37-amino acid peptide derived from the human cathelicidin family. It is a critical tool for investigating host defense mechanisms in controlled laboratory environments. Due to its amphipathic nature and positive charge, LL-37 is primarily utilized to study peptide-lipid membrane interactions, membrane disruption mechanisms, and peptide structural dynamics in solution. Kimera Chems supplies this material as a high-purity lyophilized powder for use in in vitro and analytical research.

Technical Specifications

Research Applications

LL-37 serves as a specialized structural probe for examining host defense peptide activity and membrane-protein interactions.

Primary fields of in vitro laboratory investigation include:

• Lipid Experiments: Adding the peptide to artificial membranes to observe insertion dynamics and lipid bilayer disruption.

• Structural/Folding Studies: Analyzing peptide conformation and structural changes within varying solvent environments before membrane contact.

• Microbial Membrane Interaction: Studying interactions with bacterial membrane models in controlled culture environments.

• Cell Culture Work: Analyzing binding events and signaling effects in immune cell culture models.

• Binding Kinetics: Measuring the strength and nature of the peptide’s attachment to target lipid molecules.

Storage & Handling Guidelines

To maintain the stability and experimental validity of the lyophilized peptide, the following laboratory protocols are required:

• Lyophilized Material: Store at room temperature, ensuring the material is kept away from direct light.

• Reconstituted Material: Samples should be kept in a refrigerator.

• Long-Term Storage: The material must be stored in a freezer.

• Environmental Control: Keep the container tightly sealed after each use. Store in a dry place with a desiccant to prevent atmospheric moisture degradation.

• Aseptic Technique: Handle with clean laboratory tools to avoid contamination.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medication, or dietary supplement, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these high-purity research materials solely to professional laboratories and qualified scientific investigators for authorized study.