Name: Sermorelin
SKU: ki-1784397342182-24
Price: 39.99 USD
Availability: InStock

Sermorelin is available from Kimerachems for controlled laboratory and analytical research. Review the product-specific information, available formats and documentation below before ordering.

Sermorelin (GHRH 1–29) Research Standard

Sermorelin (GHRH 1–29) is a synthetic peptide analog comprising the first 29 amino acids of the endogenous human growth hormone–releasing hormone (GHRH). It is designed to act as a potent GHRH receptor (GHRH-R) agonist, stimulating the anterior pituitary gland to release growth hormone (GH) in a physiologic, pulsatile manner. In laboratory research, Sermorelin serves as a key reference compound for investigating the dynamics of the hypothalamic–pituitary–somatotropic axis and endocrine feedback mechanisms.

Technical Specifications

Property	Specification
Product Name	Sermorelin (GHRH 1–29)
Peptide Sequence	Tyr–Ala–Asp–Ala–Ile–Phe–Thr–Asn–Ser–Tyr–Arg–Lys–Val–Leu–Gly–Gln–Leu–Ser–Ala–Arg–Lys–Leu–Leu–Gln–Asp–Ile–Met–Ser–Arg
CAS Number	86168-78-7 (Acetate form)
Molecular Weight	~3,357.9 g/mol (Peptide backbone)
Chemical Class	Synthetic GHRH analog peptide
Physical Appearance	White to off-white lyophilized powder
Solubility	Water and buffered aqueous solutions

Mechanism of Action & Research Context

Sermorelin’s utility in research is defined by its ability to engage the natural hormonal feedback loops of the pituitary gland.

GHRH-R Agonism: As a targeted agonist, Sermorelin binds to GHRH receptors located on pituitary somatotrophs. This binding triggers the stimulation of endogenous growth hormone secretion.
Signaling Pathway: The interaction activates the cAMP/PKA signaling pathways within the cell, a critical step in the regulatory cascade of GH release.
Physiologic Pulsatility: Unlike exogenous GH administration, Sermorelin is studied for its ability to mimic the body’s endogenous rhythm. It supports the maintenance of physiologic pulsatility, allowing researchers to study how hormones are released in regulated bursts rather than constant infusion.
Endocrine Feedback: It is a valuable tool for observing the hypothalamic–pituitary–somatotropic axis in operation, including how it engages native feedback mechanisms.

Research Applications

Sermorelin is a specialized reagent essential for endocrine and neurobiological research models.

Primary fields of in vitro and in vivo laboratory investigation include:

Growth Hormone Signaling: Measuring the efficacy of GHRH-R activation in isolated pituitary cell cultures.
Endocrine Feedback Loops: Studying the regulation of GH release under controlled feedback conditions.
Age-Related Axis Regulation: Investigating changes in pituitary responsiveness to GHRH agonists across different cellular models.
Comparative Secretagogue Studies: Serving as a comparative benchmark when evaluating the potency or specificity of growth hormone-releasing peptides (GHRPs).

Storage & Handling Guidelines

To maintain the chemical stability and experimental reliability of the peptide:

Storage Environment: Keep the lyophilized powder in a cold, dry place. Maintain at temperatures below 0°C (typically -20°C) for long-term stability.
Light Protection: Protect strictly from direct light to prevent the degradation of the peptide sequence.
Reconstitution: Use sterile, buffered aqueous solutions for reconstitution. Aliquot the solution immediately after preparation to minimize freeze-thaw cycles.
Aseptic Technique: Handle with clean, sterile laboratory tools in a controlled environment to prevent enzymatic or microbial contamination.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.

CAS Number	86168-78-7
Other Names	Sermorelina, Somatoliberin, UNII-89243S03TE, SCHEMBL34139, DTXSID70903978
IUPAC Name	(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular Formula	C₁₄₉H₂₄₆N₄₄O₄₂S
Molecular Weight	3357.9

Product FAQs

What is Sermorelin supplied for?

This material is supplied strictly for controlled, non-clinical laboratory and analytical research. It is not intended for human or animal consumption.

Which formats are available for Sermorelin?

Available formats or options are shown in the product selector above. Current availability can change.

Where can I review product documentation?

Where available, batch documentation can be reviewed in the Certificate of Analysis library before ordering.

Sermorelin