Thymosin Beta-4 (TB-500) is available from Kimerachems for controlled laboratory and analytical research. Review the product-specific information, available formats and documentation below before ordering.

Thymosin Beta-4 (Tβ4 / TB-500) Research Standard

Thymosin Beta-4 (Tβ4), researched in its synthetic peptide form as TB-500, is a critical regulatory protein essential for cytoskeletal organization and cellular homeostasis. In laboratory research, it is utilized as a foundational tool for investigating the dynamics of G-actin sequestration, which governs the polymerization and depolymerization of the actin cytoskeleton. By providing a chemically defined, synthetic peptide sequence, Tβ4 (TB-500) allows for the precise study of wound-response signaling, cellular migration, and angiogenic pathways without the variability associated with native protein isolates.

Technical Specifications

Property	Specification
Product Name	Thymosin Beta-4 (Tβ4 / TB-500)
CAS Number	885340-08-9
Chemical Formula	C₂₁₂H₃₅₀N₅₆O₇₈
Molecular Weight	4,961.5 g/mol
Peptide Length	43 amino acids
Chemical Class	Synthetic peptide (Thymosin Beta-4)
Physical Appearance	White to off-white lyophilized powder
Solubility	Water and buffered aqueous solutions

Mechanism of Action & Research Context

Thymosin Beta-4 functions as a primary actin-sequestering molecule, playing a regulatory role in cell structure and motility.

Actin Dynamics: The peptide binds to G-actin (monomeric actin), regulating the equilibrium between polymerization and depolymerization. This is fundamental to cellular structural maintenance.
Wound-Response & Migration: By modulating the cytoskeleton, Tβ4 is studied for its capacity to facilitate cell motility. Research models frequently utilize the peptide to examine the acceleration of wound-closure kinetics and directional cell migration.
Angiogenic Signaling: Beyond structural support, Tβ4 is investigated for its potential to stimulate endothelial cell activation and the development of new vascular networks, acting as a signaling peptide in ischemic or damaged tissue models.
Non-Receptor Signaling: Tβ4 is distinct because it does not rely on a classical surface receptor; rather, it functions as a structural signaling peptide that influences multiple downstream pathways vital for regeneration and tissue response.

Research Applications

Thymosin Beta-4 is a highly specialized reagent for structural and regenerative biology.

Primary fields of in vitro and animal-model laboratory investigation include:

Actin Cytoskeleton Modeling: Mapping the regulation of actin polymerization in response to various chemical or structural stressors.
Cellular Migration Studies: Evaluating the peptide’s ability to enhance directional migration in scratch-assay models and other kinetic movement studies.
Vascular Research: Probing the role of Tβ4 in endothelial cell signaling and the formation of vascular structures.
Regenerative Biology: Investigating the interplay between Tβ4, inflammation, and tissue remodeling after injury.

Storage & Handling Guidelines

To maintain the chemical stability and experimental reliability of the peptide:

Storage Environment: Store the lyophilized powder in a dry, cool environment. Maintain at temperatures below 0°C (typically -20°C) for long-term stability.
Light Sensitivity: Protect strictly from direct light to prevent the degradation of the peptide sequence.
Integrity: Ensure the container is kept tightly sealed to prevent moisture ingress.
Aseptic Technique: Handle with clean, sterile laboratory equipment. Once reconstituted, aliquot the solution immediately to minimize repeated freeze-thaw cycles and maintain the structural integrity of the peptide.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medical treatment, dietary supplement, or food ingredient, and is strictly prohibited for human or animal consumption. Kimera Chems supplies this high-purity research material solely to qualified institutions and professional investigators for authorized laboratory research.

CAS Number	885340-08-9
Other Names	Thymosin beta4, Thymosin beta4 Acetate, TB500, TB 500, Thymosin beta(4)
IUPAC Name	(4S)-4-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-4-amino-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid
Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight	4963

Product FAQs

What is Thymosin Beta-4 (TB-500) supplied for?

This material is supplied strictly for controlled, non-clinical laboratory and analytical research. It is not intended for human or animal consumption.

Which formats are available for Thymosin Beta-4 (TB-500)?

Available formats or options are shown in the product selector above. Current availability can change.

Where can I review product documentation?

Where available, batch documentation can be reviewed in the Certificate of Analysis library before ordering.

Thymosin Beta-4 (TB-500)