ARA-290

ARA-290

ARA-290 (also identified as Cibinetide) is a synthetic 11-amino acid peptide belonging to the helix B surface peptide (HBSP) family. Derived from the structural configuration of erythropoietin (EPO), ARA-290 is designed to interact selectively with a specific heteromeric receptor complex consisting of the erythropoietin receptor (EPOR) and the beta common receptor (βcR). In laboratory settings, this compound is extensively utilized across various in vitro and in vivo models to investigate structural binding specificity, cytoprotective pathway mechanics, and cellular signaling networks without triggering classical erythropoietic pathways.

Technical Specifications

Research Applications & Mechanism of Interest

In laboratory science, ARA-290 serves as a highly targeted reference ligand for evaluating non-hematopoietic tissue protection signaling mechanisms. Because its specific sequence isolates the tissue-protective properties of native erythropoietin from red blood cell production pathways, it gives researchers a precise tool to map ligand-receptor kinetics at the EPOR/βcR interface.

To maintain strict laboratory control and experimental reproducibility, Kimera Chems relies on a comprehensive dual-method verification protocol combining High-Performance Liquid Chromatography (HPLC) and CHN elemental analysis to independently audit and confirm the exact chemical identity, net mass, and total purity profile of each batch.

Primary fields of investigative research include:

• Heteromeric Receptor Binding: Evaluating binding kinetics, affinity markers, and structural activation thresholds unique to the EPOR/βcR complex.

• Cell Signaling Networks: Tracking signal transduction pathways involved in localized cell repair, cellular integrity preservation, and stress-response pathways.

• In Vitro Model Systems: Exploring cellular survival mechanisms, inflammatory modulation, and structural expressions inside specialized neuronal or endothelial cell cultures.

• Comparative Ligand Analysis: Benchmarking ARA-290 against native EPO and other engineered derivatives to isolate non-hematopoietic receptor behavior.

• Pathway Mapping Studies: Documenting how the compound behaves in localized biological frameworks to better map structural tolerance and molecular footprints.

Storage & Handling Guidelines

To maintain molecular integrity and ensure consistent, reproducible results in analytical assays, researchers must adhere to precise laboratory storage guidelines:

• Long-Term Storage: Store the material in a deeply frozen environment (-20°C or lower) to halt degradative processes and secure peptide stability.

• Short-Term Maintenance: Keep immediate-use or reconstituted assay volumes strictly refrigerated at 2–8°C.

• Atmospheric Controls: Protect the compound from ambient moisture, humidity, and atmospheric heat by keeping containment units securely sealed.

• Photolytic Protection: Store the compound inside amber or opaque laboratory vessels to completely shield it from direct light and UV exposure.

Research Use Only Disclaimer: This product is distributed and sold strictly as a Research Use Only (RUO) compound. It is not a drug, licensed medication, or dietary supplement, and is strictly prohibited for human or veterinary consumption. Kimera Chems supplies these materials exclusively to qualified scientific institutions and professional investigators for use within controlled in vitro laboratory frameworks.