Larazotide

Larazotide (AT-1001)

Larazotide (also identified as AT-1001 or AT-2347) is a synthetic octapeptide and a member of the tight junction modulator class. Composed of a specific sequence of amino acids with both hydrophobic and hydrophilic side chains, this compound is utilized in laboratory settings to investigate molecular interactions with cell junction proteins. Researchers employ this peptide in cell-free binding assays and in vitro models to map binding affinities and structural dynamics at tissue interfaces, providing a framework for understanding peptide-protein interactions.

Technical Specifications

Research Applications

Larazotide serves as a specialized structural probe for examining tight junction modulation and protein binding dynamics in controlled laboratory environments.

Primary fields of in vitro laboratory investigation include:

• Peptide Binding: Measuring interactions and binding affinity with isolated protein preparations.

• Conformation Studies: Analyzing structural integrity and peptide conformation in aqueous solution.

• Stability Testing: Monitoring degradation profiles and chemical integrity under varying pH and temperature conditions.

• Binding Kinetics: Determining association and dissociation rates for complex protein-peptide interactions.

Storage & Handling Guidelines

To maintain the stability and experimental validity of the lyophilized peptide, the following laboratory protocols are required:

• Lyophilized Material: Store at room temperature, ensuring the material is kept away from direct light.

• Reconstituted Material: Samples should be kept in a refrigerator.

• Long-Term Storage: The material must be stored in a freezer.

• Environmental Control: Keep the container tightly sealed after each use and place in a dry environment with a desiccant to prevent atmospheric moisture degradation.

Research Use Disclaimer

Research Use Only Disclaimer: This product is developed and distributed strictly as a Research Use Only (RUO) laboratory reference chemical intended exclusively for non-clinical analytical and scientific investigation. It is not an FDA-approved drug, medication, or dietary supplement, and is strictly prohibited for human or animal consumption. Kimera Chems supplies these high-purity research materials solely to professional laboratories and scientific institutions for authorized study.